Top 5 Isekai Anime With A Female Lead – 2021 Has Seen More Titles But Are There Enough?

Top 5 Isekai Anime with Female Main Character
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Long time readers will not be surprised when I say that I really kind of love the isekai genre. Even when faced with pretty ordinary to terrible series, I still kind of find the basic premise of isekai intriguing enough to keep on trying. What I have found though is that it is a field saturated by male protagonists and so it is really great when I come across an isekai anime with a female lead.

Even better when that lead turns out to be a fun character.

I will point out that having spent quite a bit of 2020 on apps reading manga and light novels, I’ve found that there are actually a lot of female main characters out there that have just never made it into anime form. Hopefully a few more of them do and 2021 has so far been a great year for brining female leads to isekai anime.

And given how many isekai anime there are it would be great to see a wider range of protagonists taking centre stage (not just females but just a wider range of personality types with different objectives).

As always, I’d love to know who you would have picked so be sure to give some shout outs to your favourite isekai anime with a female lead in the comments below.

Though I have deliberately left out anime like Spirited Away because it is a movie and not a series and I’ve also left out choices such as Shiro from No Game, No Life as she’s sharing the lead with Sora, when he isn’t overshadowing her.

Isekai Anime With A Female Lead No. 5: Ascendance of A Bookworm

I didn't love Main from the beginning - but she grew on me.
Ascendance of a Bookworm - an example of an isekai anime with a female lead.

Those who have followed my blog for a long time will know that Ascendance of a Bookworm didn’t click with me immediately. Largely because out female lead, ‘Main’, just didn’t work for me. I found her whiney and a little bit selfish and it was really kind of hard to get behind her.

Fortunately, she goes through quite a bit of growth and the support cast are pretty solid. By the end of the first season I was pretty much sold on this and it is definitely an isekai anime with a female lead worth watching, not just because they are hard to come by but because it offers a slightly different take on the isekai genre.

One thing I particularly loved was that they didn’t race through Main’s childhood and while she has the memories of an adult, she very much faces the limitations of a child throughout the series and while Jobless Reincarnation takes a similar path, Main and her journey do offer something a little unique.

Isekai Anime With A Female Lead No. 4: I’ve Been Killing Slimes for 300 Years and Maxed Out My Level

Azusa is rocking that hat.
Slime 300 - An example of an isekai anime with a female lead.

A recently finished anime, I’ve Been Killing Slimes for 300 Years is not only an isekai anime with a female lead, but it is an isekai anime with a pretty much exclusively female cast. The very few males who appear in the story at all are very much bit characters who largely don’t even get names and the cute female cast definitely dominate the screen.

While the plot of I’ve Been Killing Slimes for 300 Years isn’t exactly a strength with the anime choosing a more slice-of-life approach, there are magical fights strewn throughout the series and even an episode with a fighting tournament so while it isn’t quite the same kind of power fantasy usually thrown up by isekai stories there’s still plenty to enjoy.

Azusa, as a female protagonist, starts out in an interesting manner and it is great that her past life continues to exert influence on her choices. While it would have been nice to see a little more development from her, she’s still a pretty awesome example of a female lead in an isekai anime.

Isekai Anime With A Female Lead No. 3: The Saint’s Magic Power is Omnipotent.

Sei from The Saint's Magic Power is Omnipotent.
An example of an isekai anime with a female lead from spring 2021.

I’ll be reviewing The Saint’s Magic Power is Omnipotent in its entirety very soon and I’ve already posted my first impressions of the series. For an isekai anime with a female lead they’ve really given us an interesting female lead. Sei is inquisitive, smart, and on finding herself in another world and not being picked to be the saint (initially at least) she sets out to find something to do to feel useful.

All the way through the series Sei works hard and even on being declared the saint remains hard working and dedicated to improving herself, not so that people will be amazed by her, but to give herself a sense of self-worth.

When you throw in a romance story that is very much straight out of a fairy tale, you have an isekai anime with a female lead that manages to provide a solid female character but doesn’t feel the need to have her forego a beautiful romance just to prove she can stand on her own.

I’d definitely love to see another season of this anime.

Isekai Anime With A Female Lead No. 2: Didn’t I Say To Make My Abilities Average in My Next Life

Didn't I Say To Make My Abilities Average in my Next Life - An example of an isekai anime with a female lead worth watching.

Didn’t I Say To Make My Abilities Average in My Next Life was an anime that had the advantage of my going into it having already read some of the light novels and thoroughly enjoyed them. While the anime itself is fairly mediocre, as an example of an isekai anime with a female lead, Average really does what it needs to do.

Mile is a really fun character to spend time with and she’s really stupidly overpowered and could probably give most male isekai protagonists a run for their money in terms of who has the most cheat abilities. That doesn’t mean she doesn’t work for her success, but it does mean that a lot of her work is around playing down her extraordinary abilities.

Throw in a cast of adorable female characters who support Mile and really you have a very female friendly isekai anime that still manages to have adventure and fight sequences that are pretty fun to watch.

Isekai Anime With a Female Lead No. 1: My Next Life as a Villainess: All Routes Lead To Doom

My Next Life as a Villainess - An example of an isekai anime with a female lead.

A style of isekai story that I’ve found a lot in light novels and manga is for female characters to be reincarnated within video games or romance novels they were reading. And quite frequently appearing as the villain or antagonist of the story, if not a minor character who is killed off, leading to a central conflict of finding a way to change the story and survive.

My Next Life as a Villainess is one such story and I will admit, the anime was a great deal of fun. More fun than it really should have been, and largely this was thanks to the brilliant female lead, Catarina (Katarina), who is just such a fun character to spend time with.

For an isekai anime with a female lead, Villainess manages to actually provide a nice balance of male and female characters, provides some tension and conflict, has a focus on fun and romance, and never takes itself too seriously. It’s kind of the perfect binge watch experience and hopefully season 2 lives up to the same standard.

That’s my top 5 isekai Anime with A female lead – What are yours?

Top 5 Isekai Anime with Female Main Character

Thank-you for reading 100 Word Anime.
Join the discussion in the comments.
Karandi James


12 Days of Anime Characters – Ani

12 Days of Anime Title Image

Onto day three of the 12 Days of Anime and today we shift our focus from a side character who deserves more (Shimada) to a Princess in a harem comedy anime. Her character shouldn’t work anywhere near as well as it did but that is part of what makes her memorable.

Ani Inako from Dame x Prince Anime Caravan takes centre stage for Day 3 of our 12 Days of Anime.

Dame X Prince Anime Caravan Episode 2 Ani

Ani is a female protagonist at the centre of a harem of Princes in a parody that doesn’t quite land its mark as often as it should. She’s regularly covered in pink with a flower in her hair, she’s a Princess of her people with a male knight who is also probably into her, and everything about her screams we’ve seen this character before moving on. 

And that assessment isn’t really wrong, but it isn’t really right. Ani is quite the caustic and grounded young lady. She’s happy as a Princess and not trying to evade responsibilities or moaning about it, but she’s also someone who gets in and helps her people in the fields or whatever else needs to happen. Her reactions to each of the excessively pampered and very silly Princes are fairly priceless and she’s generally great fun to follow around.

Dame x Prince Anime Caravan Episode 4

However, she isn’t just the sarcastic one-line character. Ani does work hard to connect with the Princes and to help them through their problems. Part of this is her own protagonist nature that generally compels main characters to be sticky beaks and get involved (in order for the plot not to screech to a halt) and the other part is that she’s a practical young lady and these princes are the people she will need to deal with as a Queen. They are essential to the survival of her country and so personal views or not, she isn’t about to burn any bridges, though I would have forgiven her if she’d tried to drown Narek.

Dame X Prince Anime Caravan Episode 2

All and all, I really liked Ani’s character. While I might have liked a strong anime overall, I still feel hers is a character worth remembering and I’m really glad I followed her on her journey.

Thanks for reading
Karandi James
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Lara Croft: Tomb Raider Movie Review

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Lara Croft: Tomb Raider Overview:

Based on the games, Tomb Raider follows Lara Croft as she raids tombs? Not really. She finds a device hidden inside a clock that apparently is some big deal and some ancient cult have been trying to track down forever.

What follows are a bunch of action set pieces before she kind of joins forces with them to find out what will happen when they get the fancy triangle all assembled and then some more action set pieces.

Lara Croft: Tomb Raider Review:

I love action films and I particularly love action films that don’t have the only female character being a damsel in distress. I also was a massive fan of the Tomb Raider games growing up (though I was not great at playing them because half the time I couldn’t figure out the difference between walls I could climb, rocks I could pull, or holes in the ground that I was about to fall down – the graphics, while awesome for the time, left much to be desired).

So when this film came out in 2001 I really wanted it to be amazing.

Lara Croft Tomb Raider

What I got was a reasonably decent if generic action movie, a product of its time, and while there were enough stylistic nods to the character designs of the game, the actual plot left a little bit to be desired. I did enjoy watching Lara Croft: Tomb Raider but part of me always laments the ‘what could have been’ part of this film.

The list of concerns starts with Angelina Jolie as the titular Lara Croft. I was so excited when I saw she was going to take on this role. After seeing her performance in Girl Interrupted I was sold on the idea that Angelina could breathe life into a video game character who might be memorable but not so much for her personality (though she does deliver some good one-liners). Unfortunately, that isn’t what happened.

Instead we see Angelina working very hard at looking tough or pouty and that is more or less the extent of Lara’s emotional range in this film. I get she’s meant to be a strong female character who is capable of taking on the guys but some more nuanced expressions might be nice. The closest we got was Lara laughing during a fight sequence in a way that I guess was supposed to show us just how tough she was because she could laugh while bullets flew everywhere.

Even if we accept that Angelina actually played Lara pretty much the way Lara is presented in most of the games we have the script itself. While some lines hit their mark such as Lara’s, “I’ve always found your ignorance quite amusing” others just land flat on the floor and then sit there while the characters kind of wait for the next thing to happen. “It’s a clock. It ticks. It’s wrong.” Thanks for pointing that out.



Then we have the action itself. Sometime in the late 1990’s, somehow people got it into their head that an action movie is made by coming up with a number of action scenarios with major set pieces and cool choreography, throw in some quick cuts and quirky camera angles, and then you can just kind of run them all together with some generic dialogue and call it a plot.

I’d point back to Terminator and Die Hard. These films got action right. They had an excellent core to their stories that was simple and yet drove every event that followed. Terminator, was simply “kill Sara Connor”. Right from the start, that’s what we were aiming for. Every action sequence had something to do with either achieving that goal or preventing it. Die Hard had terrorists in a building. “Stop the terrorists from killing the hostages.” It’s simple and yet gives meaning to every action scene in the film.

Tomb Raider starts with a massively over the top action sequence against a robotic adversary that is revealed at the end of the sequence to be just part of Lara’s training regime. It is a cool sequence, don’t get me wrong. But what do we learn? Do we know what the story is? Is Lara’s ability to hang upside down going to be useful later? Hey, I would even accept that somehow this film is going to be about the robot running amok. But, no. That isn’t the case.

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Instead, we go from this action sequence to some exposition about a planetary alignment (ooh) and then Lara has weird dreams which somehow lead her to find the ticking clock in her mansion (through some property destruction that seems to only exist to show how little regard Lara has for her own wealth). Follow this with a motorbike sequence (she’s awesome, she motorbikes) and so on. Admittedly, she does ride the motorbike in her mansion later for some reason.

Blast out a massively overblown soundtrack and presto action movie of the early 2000’s here we are.

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Again, this doesn’t take away from any one of the action set pieces. There are some incredibly interesting enemies (if slightly unbelievable) and the setting changes so regularly you can’t possibly complain about the variety. It just makes it difficult to care about the outcome of any particular sequence when as an audience we’ve really been given no reason to care.

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Before I wrap up, I do want to touch on the ‘villain’ of the piece. While he has the right amount of slime going on with his dialogue delivery and his lines are about as good as you could expect given the rest of the dialogue, I just don’t think he ever presents enough of a threat to actually make this seem like anything more than Lara goes on a fetch quest while things get shot.

That said, I did enjoy this film. It is great like so many generic action movies for sitting back with some snacks and switching off. You’ll get a few laughs and the fight sequences are worth watching. Will you get anything more than that? Probably not.

If you watched Tomb Raider what did you think?


Thank-you for reading 100 Word Anime.
Join the discussion in the comments.
Karandi James